Sektion Biologie

biol-244 Population Genomics

Modulnummer biol244
Modulname Population Genomics
Studiengang und –abschnitt Master of Science/Education Biologie
Wahlmodul zu biol201, biol405, biol408
Fachspezifische Vertiefung „Biodiversität und Evolution“
Häufigkeit des Angebots einmal im Studienjahr,  Wintersemester
Modulverantwortliche Prof. Dr. Eva Stukenbrock
Studienberatung zum Modul Prof. Dr. Eva Stukenbrock
Lehrveranstaltungen und Dozenten Seminar: Prof. Dr. Eva Stukenbrock, Julien Y. Dutheil with Post doc
Übung: Prof. Dr. Eva Stukenbrock, Julien Y. Dutheil with Post doc
Vorkenntnisse Bachelor of Science
Sprache Deutsch/Englisch
Plätze 12
Lehrformen (Präsenzstunden (P) / Seminar 2 SWS; PräsZeit: 21 h, Vor-Nachber:10,5 h
Übung 6 SWS; PräsZeit: 63 h, Vor-Nachber: 10,5 h
Art und Gewichtung der  
Prüfungsleistungen Vortrag (100%)
Ausweis Bei Anmeldung im Prüfungsamt
Europ. Credit Points des Moduls 5
Ziele des Moduls

Advances in next generation sequencing techniques allow the analyses of genomic data from multiple individuals of the same species. “Population genomics” is the field wherein patterns of genetic variation across full genomes of many individuals is analysed. By assessing the distribution of variable sites in coding and non-coding parts of the genome, we can learn about the effects of natural selection, recombination, genetic drift and effective population size on genome evolution. The course will give an introduction into key concepts in the field of population genomics and introduce methods for analyses of population genomic data.

Inhalte des Moduls The module will present the concepts of population genomics and relate these to “traditional” population genetics. The concepts presented and discussed in the course will be explained with examples from primary literature including population genomics studies of Primates, Insects, Plants, and Fungi. The common features as well as the particularities of these examples will be emphasized. Computer exercises will be conducted with real data. Analyses of population genomic datasets will include SNP calling, analyses of SNP data, inference of natural selection and comparisons of within species structural genome variation.
Vermittelte Kompetenzen

Students understand and discuss concepts in population genomic analyses, including variation of population genetics parameters along the genome (effective population size, recombination rate, mutation rate, GC content etc).

The students will be introduced to genome browsers and learn to use these. Analyses of real population genomic data will provide the students with insight into genome analyses, including software and data formats. The attendants will learn how to read, process and analyze of comparative genomic data such as multiple genome alignments and variant calls (SNPs).

Michael Lynch

The origins of genome architecture

Sinauer associates

Chapter 4: Why Population Size Matters

Chapter 6: The Nucleotide Composition Landscape

Chapter 8: Genomic Expansion by Gene Duplication